(℞) Prescription required. Can not be split. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
(re'' goe raf' e nib)Regorafenib may cause liver damage, which may be severe or life-threatening. Tell your doctor if you have or have ever had liver disease. If you experience any of the following symptoms, call your doctor immediately: yellowing of the skin or eyes, nausea, vomiting, dark colored urine, pain in the upper right part of the stomach, extreme tiredness, unusual bleeding or bruising, lack of energy, loss of appetite, flu-like symptoms, or a change in sleep habits. Keep all appointments with the laboratory. Your doctor will order certain lab tests before and during your treatment to be sure that it is safe for you to take regorafenib and to check your body's response to the medication.
Before taking regorafenib,
- tell your doctor and pharmacist if you are allergic to regorafenib, any other medications, or any of the ingredients in regorafenib tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); certain antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); atorvastatin (Lipitor, in Caduet); clarithromycin (Biaxin, in Prevpac); fluvastatin (Lescol); irinotecan (Camptosar); methotrexate (Otrexup, Rasuvo, Trexall); rifampin (Rifadin, Rifamate, in Rifater); or telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort. You should not take St. John's wort while taking regorafenib.
- tell your doctor if you have a wound that has not healed or if you have or have ever had bleeding problems, high blood pressure, chest pain, or heart, kidney or liver disease. Also tell your doctor if you recently had surgery.
- tell your doctor if you are pregnant or plan to become pregnant. If you are a female, you should not become pregnant while you are taking regorafenib and for up to 2 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you are male, you and your female partner should use birth control during your treatment and continue to use birth control for 2 months after your final dose. If you or your partner become pregnant while taking regorafenib, call your doctor. Regorafenib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breastfeed during your treatment with regorafenib and for up to 2 weeks after your final dose.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking regorafenib. Your doctor probably will tell you to stop taking regorafenib at least 2 weeks before your surgery. Your doctor will tell you when it is safe for you to start taking regorafenib again after your surgery.
- loss of appetite
- swelling, pain, and redness of the lining of your mouth or throat
- weight loss
- hoarseness or other change in the sound of your voice
- chest pain
- shortness of breath
- unusual vaginal discharge or irritation
- burning or pain when urinating
- dizziness or feeling faint
- fever, cough, sore throat, chills, and other signs of infection
- swelling of the abdomen
- high fever
- severe diarrhea
- severe headache
- changes in vision
- dry mouth, muscle cramps, or decreased urination
- redness, pain, blisters, bleeding, or swelling on the palms of your hands or soles of your feet
- vomiting blood or vomiting material that looks like coffee grounds
- pink or brown urine
- red or black (tarry) stools
- coughing up blood or blood clots
- abnormally heavy menstrual bleeding (periods)
- unusual vaginal bleeding
- frequent nosebleeds