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(it'' ra kon' a zole)Itraconazole can cause heart failure (condition in which the heart cannot pump enough blood through the body). Tell your doctor if you have or have ever had heart failure. Your doctor may tell you not to take itraconazole. Also tell your doctor if you have or have ever had a heart attack; an irregular heartbeat; or any other type of heart, lung , liver or kidney disease. If you experience any of the following symptoms, stop taking itraconazole and call your doctor immediately: shortness of breath; coughing up white or pink phlegm; weakness; excessive tiredness; fast heartbeat; swelling of the feet, ankles, or legs; waking up at night; and sudden weight gain. Do not take cisapride (Propulsid) (not available in the U.S.), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), eplerenone (Inspra), ergot-type medications such as dihydroergotamine (D.H.E, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), methylergometrine (Methergine); felodipine (Plendil), irinotecan (Camptosar), ivabradine (Corlanor), levomethadyl acetate (Orlaam) (not available in the U.S.),lovastatin (Altoprev, in Advicor), lurasidone (Latuda), methadone (Dolophine, Methadose), midazolam (taken by mouth), nisoldipine (Sular), pimozide (Orap), quinidine (in Nuedexta), ranolazine (Ranexa), simvastatin (Zocor, in Simcor, in Vytorin), ticagrelor (Brilinta), and triazolam (Halcion) while taking itraconazole and for 2 weeks afterward. Tell your doctor if you have kidney or liver disease and are taking any of the following medication: colchicine (Colcrys, Mitigare), fesoterodine (Toviaz), solifenacin (Vesicare), or telithromycin (Ketek). Taking these medications with itraconazole can cause serious heart problems including QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Talk to your doctor about the risks of taking itraconazole.
Before taking itraconazole,
- tell your doctor and pharmacist if you are allergic to itraconazole; other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or voriconazole (Vfend); any other medications, or any of the ingredients in itraconazole products. If you are taking itraconazole oral solution, tell your doctor if you are allergic to saccharin or sulfa medications. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist if you are taking the following medications or took them in the last 2 weeks before starting treatment with itraconazole: carbamazepine (Epitol, Tegretol, Teril, others); efavirenz (Sustiva, in Atripla); isoniazid (Laniazid, in Rifamate, in Rifater); rifabutin (Mycobutin); rifampicin; nevirapine (Viramune); phenobarbital; and phenytoin (Dilantin, Phenytek).
- tell your doctor or pharmacist if you are taking the following medications: aliskiren (Tekturna, in Amturnide, Tekamlo, and Tekturna HCT), apixaban (Eliquis), axitinib (Inlyta), colchicine (Colcrys, Mitigare), dabrafemob (Taflinar), darifenacin (Enablex), dasatinib (Sprycel), everolimus (Afinitor, Zortress), ibrutinib (Imbruvica), nilotinib (Tasigna), rivaroxaban (Xarelto), salmeterol (Serevent), sildenafil (only Revatio brand used for lung disease), simeprevir (Olysio), sunitinib (Sutent), tamsulosin (Flomax, in Jalyn), temsirolimus (Torisel), trabectedin (Yondelis), and vardenafil (Staxyn, Levitra). Your doctor may tell you not to take these medications during your treatment and for 2 weeks after your treatment with itraconazole.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antibiotic medications such as ciprofloxacin (Cipro), clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S. Ery-Tab, others), and telithromycin (Ketek); anticoagulant (''blood thinner'') such as warfarin (Coumadin, Jantoven); alprazolam (Xanax); aprepitant (Emend); aripiprazole (Abilify); atorvastatin (Lipitor, in Caduet, in Liptruzet); bortezomib (Velcade); bosentan (Tracleer); budesonide (Entocort EC, Pulmicort, Uceris); buprenorphine (Buprenex, Butrans, in Bunavail; others); buspirone; ciclesonide (Alvesco, Omnaris, Zetonna); cilostazol (Pletal); cinacalcet (Sensipar); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); dexamethasone; diazepam (Valium); digoxin (Lanoxin); docetaxel (Docefrez, Taxotere); eletriptan (Relpax); erlotinib (Tarceva); fentanyl (Actiq, Duragesic, Fentora, Subsys, others); fesoterodine (Toviaz); fluticasone (Flovent, in Advair); gefitinib (Iressa); haloperidol (Haldol); HIV protease inhibitors including indinavir (Crixivan), darunavir (Prezista) taken with ritonavir, fosamprenavir (Lexiva) taken with ritonavir, and saquinavir (Invirase); imatinib (Gleevac); ixabepilone (Ixempra Kit); lapatinib (Tykerb); maraviroc (Selzentry); meloxicam (Mobic); methylprednisolone (Medrol); nadolol (Corgard, in Corzide); oxybutynin (Ditropan XL, Oxytrol); oxycodone (Oxaydo, Oxycontin, in Percodan; others); ponatinib (Iclusig); praziquantel (Biltricide); quetiapine (Seroquel); ramelteon (Rozerem); repaglinide (Prandin, in Prandimet); riociguat (Adempas); risperidone (Risperdal); saxagliptin (Kombiglyze XR, Onglyza); sirolimus (Rapamune); solifenacin (Vesicare); tacrolimus (Astagraf, Prograf); tadalafil (Adcirca, Cialis); tolterodine (Detrol); vardenafil (Levitra, Staxyn); verapamil (Calan, Covera, Verelan PM, in Tarka), vinblastine, vincristine (Marqibo Kit), and vinorelbine (Navelbine). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with itraconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on these lists.
- if you are taking an antacid, take it 1 hour before or 2 hours after you take itraconazole.
- tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section,, cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), any condition that decreases the amount of acid in your stomach, or HIV.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not take itraconazole to treat nail fungus if you are pregnant or could become pregnant. You may start to take itraconazole to treat nail fungus only on the second or third day of your menstrual period when you are sure you are not pregnant. You must use effective birth control during your treatment and for 2 months afterward. If you become pregnant while taking itraconazole to treat any condition, call your doctor.
- you should know that itraconazole may make you dizzy or cause blurred or double vision. Do not drive a car or operate machinery until you know how this medication affects you.
- gas or bloating
- unpleasant taste
- sore or bleeding gums
- muscle pain or weakness
- joint pain
- decreased sexual desire or ability
- runny nose and other cold symptoms
- hair loss
- blurred vision or double vision
- ringing in the ears
- inability to control urination or urinating more than usual
- excessive tiredness
- loss of appetite
- stomach pain
- yellowing of the skin or eyes
- dark urine
- pale stools
- feelings of numbness, tingling, pricking, burning, or creeping on the skin
- hearing loss
- increased sensitivity to light
- severe skin disorder
- hearing loss
- swelling of the face, throat, tongue, lips, eyes, hands, ankles, or lower legs
- difficulty breathing or swallowing