Odefsey (Emtricitabine / Rilpivirine Hydrochloride / Tenofovir Alafenamide)

They need to know if you have any of these conditions: -bone problems -depression -drink alcohol-containing drinks -heart disease -kidney disease -liver disease -suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member -an unusual or allergic reaction to emtricitabine, rilpivirine, tenofovir, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding

Take this medicine by mouth with a glass of water and food. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medicine with any of the following medications: -certain medicines for seizures like carbamazpine, oxcarbazepine, phenobarbital, phenytoin -certain medicines for stomach problems like dexlansoprazole, esomeprazole, pantoprazole, omeprazole, lansoprazole, rabeprazole -dexamethasone -lumacaftor; ivacaftor -rifampin -rifapentine -St. John's wort; Hypericum perforatum This medicine may also interact with the following medications: -certain antibiotics like clarithromycin, erythromycin, telithromycin, rifabutin -certain medicines for fungal infections like fluconazole, voriconazole, posaconazole, ketoconazole, itraconazole -certain medicines for stomach problems like aluminum hydroxide, magnesium hydroxide, calcium carbonate, cimetidine, famotidine, nizatidine, ranitidine -certain medicines for viral infections like cidofovir, acyclovir, adefovir dipivoxil, valacyclovir, ganciclovir, valganciclovir -methadone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine. HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV. If you have hepatitis B, talk to your doctor if you plan to stop this medicine. The symptoms of hepatitis B may get worse if you stop this medicine.

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -changes in vision -dizziness -fast, irregular heartbeat -muscle pain -nausea, vomiting, unusual upset stomach or stomach pain -redness, blistering, peeling or loosening of the skin, including inside the mouth -signs and symptoms of kidney injury like trouble passing urine or change in the amount of urine -signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin -signs of infection - fever or chills, cough, sore throat, pain or trouble passing urine -suicidal thoughts or other mood changes Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -abnormal dreams -diarrhea -headache -skin discoloration -trouble sleeping -weight gain around waist, back, or thinning of face, arms, legs

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.