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(poe'' sa kon' a zole)
Before taking posaconazole,
- tell your doctor and pharmacist if you are allergic to posaconazole; other antifungal medications such as fluconazole (Diflucan), isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel), or voriconazole (Vfend); simethicone; any other medications; or any of the ingredients in posaconazole products. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you taking any of the following medications: atorvastatin (Lipitor, in Caduet), ergot-type medications such as bromocriptine (Cycloset, Parlodel), cabergoline, dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine, ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lovastatin (Altoprev, in Advicor); pimozide (Orap); quinidine (in Nuedexta); simvastatin (Zocor, in Simcor, in Vytorin); or sirolimus (Rapamune). Your doctor will probably tell you not to take posaconazole if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam, and triazolam (Halcion); calcium channel blockers such as diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), and verapamil (Calan, Covera, Verelan, others); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); efavirenz (Sustiva, in Atripla); erythromycin (E.E.S., ERYC, Erythrocin, others), fosamprenavir (Lexiva); glipizide (Glucotrol); phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); ritonavir (Norvir) taken with atazanavir (Reyataz); tacrolimus (Astagraf, Envarsus XR, Prograf); vinblastine; and vincristine (Marquibo Kit). If you are taking the posaconazole oral suspension, also tell your doctor if you are taking cimetidine (Tagamet), esomeprazole (Nexium, in Vimovo), or metoclopramide (Reglan). Many other medications may also interact with posaconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had a slow or irregular heartbeat; a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death); problems with blood circulation; low levels of calcium, magnesium, or potassium in your blood; or kidney, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking posaconazole, call your doctor.
- chills or shaking
- swelling of the hands, feet, ankles, or lower legs
- stomach pain
- back or muscle pain
- sores on the lips, mouth, or throat
- difficulty falling asleep or staying asleep
- increased sweating
- sore throat
- unusual bruising or bleeding
- extreme tiredness
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- yellowing of the skin or eyes
- flu-like symptoms
- dark urine
- pale stools
- fast, pounding, or irregular heartbeat
- sudden loss of consciousness
- shortness of breath