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(peg fil gra' stim)Pegfilgrastim injection, pegfilgrastim-bmez, pegfilgrastim-cbqv, and pegfilgrastim-jmdb injection are biologic medications (medications made from living organisms). Biosimilar pegfilgrastim-bmez, pegfilgrastim-cbqv, and pegfilgrastim-jmdb injection are highly similar to pegfilgrastim injection and work the same way as pegfilgrastim injection in the body. Therefore, the term pegfilgrastim injection products will be used to represent these medications in this discussion.
- you should have a caregiver with you the first time you receive a dose of pegfilgrastim or anytime the prefilled automatic injection device is applied to the back of your arm.
- you will need to monitor the prefilled automatic injection device while the entire dose of pegfilgrastim is injected in your body, so you should avoid activities and being in places that may interfere with monitoring while you are receiving the dose of filgrastim and for 1 hour afterwards.
- you should not travel, drive a car, or operate machinery 1 hour before and 2 hours after you receive your dose of pegfilgrastim with the prefilled automatic injection device (about 26 to 29 hours after the it was applied).
- you should make sure that you keep the prefilled automatic injection device at least 4 inches away from electric appliances and equipment including cell phones, cordless telephones, and microwave ovens.
- you should avoid airport x-rays and request a manual pat down if you have to travel after the prefilled automatic injection device is applied to your body and before you receive your dose of pegfilgrastim.
- you should immediately remove the prefilled automatic injection device if you have an allergic reaction while you are receiving your dose of pegfilgrastim by grabbing the edge of the adhesive pad and peeling it off. Call your doctor immediately and get emergency medical treatment.
- you should call your doctor immediately if the prefilled automatic injection device comes off of your skin, if the adhesive becomes noticeably wet, if you see dripping from the device, or if the status light flashes red. You should keep the prefilled automatic injection device dry for 3 hours before you receive your dose of pegfilgrastim to help you notice if your device starts to leak while you are receiving your dose.
- you should avoid being exposed to medical imaging studies (X-ray scan, MRI, CT scan, ultrasound) or oxygen rich environments (hyperbaric chambers).
- you should avoid sleeping or applying pressure on the prefilled automatic injection device.
- you should avoid hot tubs, whirlpools, saunas, and direct sunlight.
- you should avoid using lotions, oils, creams, and cleansers on your skin near the prefilled automatic injection device.
Before using pegfilgrastim injection products,
- tell your doctor and pharmacist if you are allergic to pegfilgrastim, pegfilgrastim-bmez, pegfilgrastim-cbqv, pegfilgrastim-jmdb, filgrastim (Granix, Neupogen, Nivestym, Zarxio), any other medications, or any of the ingredients in pegfilgrastim injection products. Also tell your doctor if you or the person who will be injecting a pegfilgrastim injection product for you is allergic to latex or acrylic adhesives.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had cancer of the blood or bone marrow, or myelodysplasia (problems with bone marrow cells that may develop into leukemia).
- tell your doctor if you have sickle cell disease (a blood disease that may cause painful crises, a low number of red blood cells, infection, and damage to the internal organs). If you have sickle cell disease, you may be more likely to have a crisis during your treatment with a pegfilgrastim injection product. Call your doctor right away if you have a sickle cell crisis during your treatment.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using a pegfilgrastim injection product, call your doctor.
- you should know that pegfilgrastim injection products decrease the risk of infection but does not prevent all infections that may develop during or after chemotherapy. Call your doctor if you develop signs of infection such as fever; chills; rash; sore throat; diarrhea; or redness, swelling, or pain around a cut or sore.
- bone pain
- pain in arms or legs
- pain in the left upper part of the stomach or the tip of your left shoulder
- fever, shortness of breath, trouble breathing, fast breathing
- swelling of the face, throat, or around the mouth or eyes, hives, rash, itching, trouble swallowing or breathing
- swelling of your face or ankles, bloody or dark colored urine, decreased urination
- fever, abdominal pain, back pain, feeling unwell
- swelling of stomach area or other swelling, decreased urination, trouble breathing, dizziness, tiredness