Harvoni (Ledipasvir / Sofosbuvir)
(℞) Prescription required. Can not be split. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Ledipasvir / Sofosbuvir Information
(le dip' as vir) and (soe fos' bue vir)You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of ledipasvir and sofosbuvir may increase the risk that you will develop symptoms and your infection will become more serious or life-threatening Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of ledipasvir and sofosbuvir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea, vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of ledipasvir and sofosbuvir. Talk to your doctor about the risk(s) of taking the combination of ledipasvir and sofosbuvir.
Before taking ledipasvir and sofosbuvir,
- tell your doctor and pharmacist if you are allergic to ledipasvir or sofosbuvir, any other medications, or any of the ingredients in ledipasvir and sofosbuvir tablets or pellets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); digoxin (Lanoxin); certain medications for cancer; medications for diabetes; certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Oxtellar XR, Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); medications for heartburn and ulcers; medications for HIV taken together such as efavirenz (Sustiva, in Atripla), emtricitabine (Emtriva, in Atripla) and tenofovir (Viread, in Atripla); elvitegravir (Sustiva, in Atripla), cobicistat (Tybost, in Stribild), emtricitabine (Emtriva, in Stribild), and tenofovir (Viread, in Stribild); tenofovir (Viread), atazanavir (Reyataz) and ritonavir (Norvir); tenofovir (Viread), darunavir (Prezista) and ritonavir (Norvir); tenofovir (Viread), lopinavir (in Kaletra), and ritonavir (Norvir, in Kaletra); or tipranavir (Aptivus) and ritonavir (Norvir); certain medications that suppress the immune system; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); rifapentine (Priftin); rosuvastatin (Crestor); simeprevir (Olysio); sofosbuvir (Sovaldi); and warfarin (Coumadin, Jantoven). Your doctor may tell you not to take ledipasvir and sofosbuvir if you are taking one or more of these medications or may monitor you carefully for side effects. Many other medications may also interact with ledipasvir and sofosbuvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), take them 4 hours before or 4 hours after taking ledipasvir and sofosbuvir.
- tell your doctor if you are taking a medication for indigestion, heartburn, or ulcers (H2 blockers) such as cimetidine, ranitidine (Zantac), famotidine (Pepcid, in Duexis) or nizatidine. Your doctor may tell you to take them 12 hours before or 12 hours after ledipasvir and sofosbuvir, or at the same time that you take ledipasvir and sofosbuvir.
- tell your doctor what herbal products you are taking, especially St. John's wort. You should not take St. John's wort during your treatment with ledipasvir and sofosbuvir.
- tell your doctor if you have had a liver transplant or if you have human immunodeficiency virus (HIV). Also, tell your doctor if you have or have ever had any type of liver disease other than hepatitis C, kidney disease, or are on dialysis.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking ledipasvir and sofosbuvir, call your doctor. If ledipasvir and sofosbuvir is used in combination with ribavirin, be sure to read information about pregnancy precautions in the ribavirin monograph.
- difficulty falling asleep or staying asleep
- muscle pain
- swelling of the face, arms, or legs
- shortness of breath
- difficulty swallowing or breathing