Cellcept (Mycophenolate Mofetil)
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Mycophenolate Mofetil Information
(mye koe fen' oh late)Risk of birth defects: Mycophenolate must not be taken by women who are pregnant or who may become pregnant. There is a high risk that mycophenolate will cause miscarriage (loss of the pregnancy) during the first 3 months of pregnancy or will cause the baby to be born with birth defects (problems that are present at birth). You should not take mycophenolate if you are pregnant or if you may become pregnant. You must have a negative pregnancy test before starting your treatment with mycophenolate, again 8 to 10 days later, and at routine follow-up appointments. You must use acceptable birth control during your treatment, and for 6 weeks after you stop taking mycophenolate. Your doctor will tell you which forms of birth control are acceptable for you to use. Mycophenolate may decrease the effectiveness of oral contraceptives (birth control pills), so it is especially important to use a second form of birth control along with this type of contraceptive. If you are a male with a female partner who may become pregnant, you should use acceptable birth control during treatment and for at least 90 days after your last dose. Do not donate sperm during your treatment and for at least 90 days after your last dose. Call your doctor right away if you think you or your partner, is pregnant or if you miss a menstrual period. Because of the possibility that your donation may go to a female who may be or become pregnant, do not donate blood during your treatment and for at least 6 weeks after your last dose. Risks of serious infections: Mycophenolate weakens the body's immune system and may decrease your ability to fight infection. Wash your hands often and avoid people who are sick while you are taking this medication. If you experience any of the following symptoms, call your doctor immediately: fever, sore throat, chills, or cough; unusual bruising or bleeding; pain or burning during urination; frequent urination; wound or sore that is red, warm, or won't heal; drainage from a skin wound; general weakness, extreme tiredness, or sick feeling; symptoms of the ''flu'' or a ''cold''; pain or swelling in the neck, groin, or armpits; white patches in the mouth or throat; cold sores; blisters; headache or earache; or other signs of infection. You may be infected with certain viruses or bacteria but not have any signs of infection. Taking mycophenolate increases the risk that these infections will become more severe and cause symptoms. Tell your doctor if you have any type of infection, such as Hepatitis B or C, including an infection that does not cause symptoms. Mycophenolate may increase the risk that you will develop progressive multifocal leukoencephalopathy (PML; a rare infection of the brain that cannot be treated, prevented, or cured and that usually causes death or severe disability). Tell your doctor if you have or have ever had PML, or another condition that affects your immune system such as human immunodeficiency virus (HIV); acquired immunodeficiency syndrome (AIDS); sarcoidosis (a condition that causes swelling in the lungs and sometimes in other parts of the body); leukemia (cancer that causes too many blood cells to be produced and released into the bloodstream); or lymphoma. If you experience any of the following symptoms, call your doctor immediately: weakness on one side of the body or in the legs; difficulty or inability to control your muscles; confusion or difficulty thinking clearly; unsteadiness; memory loss; difficulty speaking or understanding what others say; or a lack of interest or concern for usual activities or things you usually care about. Mycophenolate may increase your risk of developing certain types of cancer, including lymphoma (a type of cancer that develops in the lymph system) and skin cancer. Tell your doctor if you or anyone in your family has or has ever had skin cancer. Avoid unnecessary or prolonged exposure to real and artificial sunlight (tanning beds, sunlamps) and light therapy and wear protective clothing, sunglasses, and sunscreen (with a SPF factor of 30 or above). This will help to decrease your risk of developing skin cancer. Call your doctor if you experience any of the following symptoms: pain or swelling in the neck, groin, or armpits; a new skin sore or bump; a change in the size or color of a mole; a brown or black skin lesion (sore) with uneven edges or one part of the lesion that does not look like the other; skin changes; sores that do not heal; unexplained fever; tiredness that does not go away; or weight loss. Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to mycophenolate. Talk to your doctor about the risks of taking mycophenolate.
Before taking mycophenolate,
- tell your doctor and pharmacist if you are allergic to mycophenolate, mycophenolic acid, any other medications, or any of the ingredients in the mycophenolate or mycophenolic acid product you are taking. If you are taking mycophenolate liquid, tell your doctor and pharmacist if you are allergic to aspartame or sorbitol. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: activated charcoal; acyclovir (Zovirax); certain antibiotics such as amoxicillin and clavulanic acid (Augmentin), ciprofloxacin (Cipro),, and sulfamethoxazole/trimethoprim (Bactrim); azathioprine (Azasan, Imuran); cholestyramine (Prevalite); ganciclovir (Cytovene, Valcyte); other medications that suppress the immune system; isavuconazonium (Cresemba); probenecid (Probalan); proton pump inhibitors such as lansoprazole (Dexilant, Prevacid) and pantoprazole (Protonix); rifampin (Rifadin, Rimactane, in Rifamate, Rifater); telmisartan (Micardis, in Twynsta); valacyclovir (Valtrex); and valganciclovir (Valcyte). Also tell your doctor if you are taking a combination of both norfloxacin (Noroxin) and metronidazole (Flagyl). Many other medications may also interact with mycophenolate, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Also be sure tell your doctor if you stop taking any of your medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- if you are taking sevelamer (Renagel, Renvela), or antacids that contain magnesium or aluminum, take them 2 hours after you take mycophenolate.
- tell your doctor if you have or have ever had Lesch-Nyhan syndrome or Kelley-Seegmiller syndrome (inherited diseases that cause high levels of a certain substance in the blood, joint pain, and problems with motion and behavior); anemia (a lower than normal number of red blood cells); neutropenia (less than normal number of white blood cells); ulcers or any disease that affects your stomach, intestines, or digestive system; any type of cancer; or kidney or liver disease.
- tell your doctor if you are breastfeeding.
- you should know that mycophenolate may make you drowsy, confused, dizzy, lightheaded, or cause uncontrollable shaking of a part of the body. Do not drive a car or operate machinery until you know how this medication affects you.
- do not have any vaccinations without talking to your doctor. Ask your doctor if you should get a flu vaccine before or during your treatment because taking mycophenolate may increase your risk of infection.
- if you have phenylketonuria (PKU, an inherited condition in which a special diet must be followed to prevent mental retardation), you should know that mycophenolate suspension contains aspartame, a source of phenylalanine.
- stomach pain or swelling
- difficulty falling asleep or staying asleep
- pain, especially in the back, muscles, or joints
- prickling, tingling, or burning feeling on the skin
- muscle stiffness or weakness
- diarrhea, sudden severe stomach pain
- swelling of the hands, arms, feet, ankles, or lower legs
- difficulty breathing
- chest pain
- fast heartbeat
- lack of energy
- pale skin
- unusual bleeding or bruising
- black and tarry stools
- red blood in stools
- bloody vomit
- vomit that looks like coffee grounds
- blood in urine
- yellowing of the skin or eyes