Afrezza (Insulin Recombinant Human)
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Insulin Recombinant Human Information
(in' su lin)Insulin inhalation may decrease lung function and can cause bronchospasms (breathing difficulties). Tell your doctor if you have or have ever had asthma or chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways). Your doctor will tell you not to use insulin inhalation if you have asthma or COPD. Your doctor will order certain tests to check how well your lungs are working before therapy, 6 months after starting therapy, and annually while using insulin inhalation treatment. Tell your doctor if you have any of the following symptoms: wheezing or difficulty breathing. Keep all appointments with your doctor and the laboratory. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with insulin inhalation and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the manufacturer's website to obtain the Medication Guide. Talk to your doctor about the risks of using insulin inhalation.
Before using insulin inhalation,
- tell your doctor and pharmacist if you are allergic to insulin (Apidra, Humulin, Lantus, Levemir, Novolog, others), any other medications, or any of the inactive ingredients in insulin inhalation. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: albuterol (Proair HFA, Proventil, Ventolin, others); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Zestril, in Prinzide, in Zestoretic), quinapril (Accupril, in Quinaretic), and ramipril (Altace); angiotensin II antagonists (angiotensin receptor blockers; ARBs) such as azilsartan (Edarbi), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (Diovan, in Diovan HCT, in Exforge HCT, others); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol, others), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran XL); clonidine (Catapres, Catapres-TTS, Kapvay, others); clozapine (Clozaril, Fazaclo ODT, Versacloz); danazol; disopyramide (Norpace, Norpace CR); diuretics; fenofibrate (Lipofen, TriCor, Triglide); fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax); gemfibrozil (Lopid); HIV protease inhibitors including atazanavir (Reyataz), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), and saquinavir (Invirase); hormone replacement therapy; isoniazid (Laniazid, in Rifamate, in Rifater); lithium (Lithobid); medications for asthma, colds, mental illness, and nausea; monoamine oxidase (MAO) inhibitors, including isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); niacin; oral contraceptives (birth control pills); oral medications for diabetes such as pioglitazone (Actos, in Actoplus Met, in Duetact, in Oseni) or rosiglitazone (Avandia, in Avandamet, in Avandaryl); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); octreotide (Sandostatin); olanzapine (Zyprexa, Zydis, in Symbyax); other inhaled medications; pentamidine (NebuPent, Pentam); pentoxifylline (Pentoxil); pramlintide (Symlin); propoxyphene; reserpine; salicylate pain relievers such as aspirin; somatropin (Genotropin, Humatrope, Nutropin, others); sulfa antibiotics; terbutaline; and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have symptoms of hypoglycemia (low blood sugar). Your doctor will probably tell you not to take insulin inhalation if you have this condition.
- tell your doctor if you have an infection or if you smoke or if you stopped smoking within the past 6 months. Also, tell your doctor if you have or have ever had lung cancer, nerve damage caused by your diabetes, heart failure, or kidney or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using insulin inhalation, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using insulin inhalation.
- ask your doctor how often you should check your blood sugar. Be aware that low blood sugar may affect your ability to perform tasks such as driving and ask your doctor if you need to check your blood sugar before driving or operating machinery.
- alcohol may cause a change in blood sugar. Ask your doctor about the safe use of alcoholic beverages while you are using insulin inhalation.
- ask your doctor what to do if you get sick, gain or lose weight, experience unusual stress, plan to travel across time zones, or change your exercise or activity schedule. These changes can affect your dosing schedule and the amount of insulin you will need.
- sore throat or irritation
- painful, burning urination
- weight gain
- rash or itching
- fast heartbeat
- difficulty swallowing
- shortness of breath
- swelling of the arms, hands, feet, ankles, or lower legs
- sudden weight gain
- extreme drowsiness